Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC009
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-18 08:57
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 tbl Mirapexin a 2,1mg 1 ujutru tbl Rivotril a 2mg 1/4 uvece old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 7, 'TN': 7, 'TP': 35, 'FP': 23}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 16, 'TN': 11, 'TP': 26, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 15, 'TN': 8, 'TP': 27, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 16, 'TN': 10, 'TP': 26, 'FP': 20}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 13.064
timePerCircleCoV 0.126327
timePerCircleSlope 0.00931544
meanError 1.209
tremorFreq 5.95703
tremorRelPower 55.0249
tremorGyroAmpMean 0.0568785
tremorGyroAmpSlope -0.0028932
tremorGyroAmpCoV 0.673629
tremorCoordAmpMean 0.0956963
tremorCoordAmpSlope -0.00307809
tremorCoordAmpCoV 0.586314
tremorAccAmpMean 0.0946989
tremorAccAmpSlope -0.00288647
tremorAccAmpCoV 0.613108
tremorPcRelVar 0.898126
tremorPcX 0.763189
tremorPcY -0.646176

Circle Segment 1

Duration 13.36 s, Accuracy Estimate 2.413 (lower is better)

Circle Segment 2

Duration 8.76 s, Accuracy Estimate 1.297 (lower is better)

Circle Segment 3

Duration 14.48 s, Accuracy Estimate 1.375 (lower is better)

Circle Segment 4

Duration 12.96 s, Accuracy Estimate 0.903 (lower is better)

Circle Segment 5

Duration 14.6 s, Accuracy Estimate 0.778 (lower is better)

Circle Segment 6

Duration 13.76 s, Accuracy Estimate 0.99 (lower is better)

Circle Segment 7

Duration 13.12 s, Accuracy Estimate 0.859 (lower is better)

Circle Segment 8

Duration 13.92 s, Accuracy Estimate 0.846 (lower is better)

Circle Segment 9

Duration 13.16 s, Accuracy Estimate 0.963 (lower is better)

Circle Segment 10

Duration 12.52 s, Accuracy Estimate 1.667 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 36.525
timePerSpiralCoV 0.114872
timePerSpiralSlope 0.0386037
meanError 1.68874
tremorFreq 6.05469
tremorRelPower 64.5069
tremorGyroAmpMean 0.0414569
tremorGyroAmpSlope -0.00019908
tremorGyroAmpCoV 0.406841
tremorCoordAmpMean 0.0842488
tremorCoordAmpSlope 0.00153551
tremorCoordAmpCoV 1.00727
tremorAccAmpMean 0.080121
tremorAccAmpSlope 3.59436e-05
tremorAccAmpCoV 0.387028
tremorPcRelVar 0.667309
tremorPcX -0.19455
tremorPcY 0.980893

Spiral Segment 1

Duration 29.92 s, Accuracy Estimate 1.724 (lower is better)

Spiral Segment 2

Duration 32.44 s, Accuracy Estimate 1.447 (lower is better)

Spiral Segment 3

Duration 34.32 s, Accuracy Estimate 1.798 (lower is better)

Spiral Segment 4

Duration 37.6 s, Accuracy Estimate 1.734 (lower is better)

Spiral Segment 5

Duration 39.36 s, Accuracy Estimate 1.691 (lower is better)

Spiral Segment 6

Duration 38.0 s, Accuracy Estimate 1.884 (lower is better)

Spiral Segment 7

Duration 43.32 s, Accuracy Estimate 1.702 (lower is better)

Spiral Segment 8

Duration 37.24 s, Accuracy Estimate 1.529 (lower is better)

Elel

eDurationMean 0.608421
eDurationStd 0.0995062
eDurationStdnorm 0.163548
eDurationMedian 0.59
eDurationQuartdelta 0.12
eDurationQuartdeltanorm 0.20339
eDurationKurt 3.04612
eDurationTrenddiff -0.075
eDurationTrendratio 0.879032
eWidthMean 4.94479
eWidthStd 1.3152
eWidthStdnorm 0.265978
eWidthMedian 4.68
eWidthQuartdelta 1.404
eWidthQuartdeltanorm 0.3
eWidthKurt 5.04924
eWidthTrenddiff 0
eWidthTrendratio 1
eHeightMean 5.99471
eHeightStd 0.793735
eHeightStdnorm 0.132406
eHeightMedian 5.85
eHeightQuartdelta 1.053
eHeightQuartdeltanorm 0.18
eHeightKurt 2.81846
eHeightTrenddiff 0.117
eHeightTrendratio 1.02
eAspectMean 0.819283
eAspectStd 0.150891
eAspectStdnorm 0.184175
eAspectMedian 0.833462
eAspectQuartdelta 0.203226
eAspectQuartdeltanorm 0.243833
eAspectKurt 2.54192
eAspectTrenddiff -0.0242347
eAspectTrendratio 0.971037
eSlantMean 0.131087
eSlantStd 0.246756
eSlantStdnorm 1.88239
eSlantMedian 0.154545
eSlantQuartdelta 0.348214
eSlantQuartdeltanorm 2.25315
eSlantKurt 2.34318
eSlantTrenddiff -0.00909091
eRtopMean 0.765043
eRtopStd 0.120513
eRtopStdnorm 0.157524
eRtopMedian 0.807033
eRtopQuartdelta 0.220085
eRtopQuartdeltanorm 0.272709
eRtopKurt 2.12781
eRtopTrenddiff -0.0681818
eRbotMean 0.633868
eRbotStd 0.22689
eRbotStdnorm 0.357946
eRbotMedian 0.645513
eRbotQuartdelta 0.276101
eRbotQuartdeltanorm 0.427723
eRbotKurt 2.87571
eRbotTrenddiff -0.00897436
eRrightMean 0.876211
eRrightStd 0.0706738
eRrightStdnorm 0.0806584
eRrightMedian 0.892361
eRrightQuartdelta 0.0762176
eRrightQuartdeltanorm 0.0854111
eRrightKurt 3.78315
eRrightTrenddiff -0.0590909
eRleftMean 0.316257
eRleftStd 0.104489
eRleftStdnorm 0.330394
eRleftMedian 0.315341
eRleftQuartdelta 0.1625
eRleftQuartdeltanorm 0.515315
eRleftKurt 2.2835
eRleftTrenddiff 0.0669388
lDurationMean 0.907368
lDurationStd 0.153863
lDurationStdnorm 0.169571
lDurationMedian 0.885
lDurationQuartdelta 0.25
lDurationQuartdeltanorm 0.282486
lDurationKurt 2.23572
lDurationTrenddiff -0.195
lDurationTrendratio 0.808824
lWidthMean 11.8262
lWidthStd 2.07813
lWidthStdnorm 0.175722
lWidthMedian 11.5245
lWidthQuartdelta 3.393
lWidthQuartdeltanorm 0.294416
lWidthKurt 2.28614
lWidthTrenddiff 1.404
lWidthTrendratio 1.13187
lHeightMean 16.0937
lHeightStd 1.95603
lHeightStdnorm 0.12154
lHeightMedian 15.561
lHeightQuartdelta 3.042
lHeightQuartdeltanorm 0.195489
lHeightKurt 2.30008
lHeightTrenddiff 0.819
lHeightTrendratio 1.05385
lAspectMean 0.732616
lAspectStd 0.0706175
lAspectStdnorm 0.0963908
lAspectMedian 0.73769
lAspectQuartdelta 0.0967532
lAspectQuartdeltanorm 0.131157
lAspectKurt 2.21976
lAspectTrenddiff 0.0144734
lAspectTrendratio 1.01972
lSlantMean 0.358593
lSlantStd 0.104706
lSlantStdnorm 0.291992
lSlantMedian 0.348045
lSlantQuartdelta 0.143642
lSlantQuartdeltanorm 0.412711
lSlantKurt 2.4719
lSlantTrenddiff 0.00859771
lRtopMean 0.827466
lRtopStd 0.0673046
lRtopStdnorm 0.0813382
lRtopMedian 0.839311
lRtopQuartdelta 0.0915751
lRtopQuartdeltanorm 0.109107
lRtopKurt 3.17266
lRtopTrenddiff 0.0036215
lRbotMean 0.339727
lRbotStd 0.0865018
lRbotStdnorm 0.254622
lRbotMedian 0.327356
lRbotQuartdelta 0.140547
lRbotQuartdeltanorm 0.42934
lRbotKurt 2.03953
lRbotTrenddiff -0.00889894
lRrightMean 0.905319
lRrightStd 0.0430787
lRrightStdnorm 0.047584
lRrightMedian 0.904436
lRrightQuartdelta 0.0567059
lRrightQuartdeltanorm 0.0626975
lRrightKurt 3.52184
lRrightTrenddiff -0.0100306
lRleftMean 0.190061
lRleftStd 0.0504035
lRleftStdnorm 0.265197
lRleftMedian 0.189496
lRleftQuartdelta 0.0610066
lRleftQuartdeltanorm 0.321942
lRleftKurt 4.34319
lRleftTrenddiff -0.0197982

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.90805
sumTouchScores 4.54025
meanMovementTime 0.43625
numTouches 5
undershootPercentage 20
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.86131
sumTouchScores 18.0875
meanMovementTime 0.91225
numTouches 21
undershootPercentage 0
overshootPercentage 33.3333

ZigZag

numZigzags 5
timePerZigzagMean 17.816
timePerZigzagCoV 0.0508173
timePerZigzagSlope -0.0179614
meanError 2.36322
tremorFreq 5.95703
tremorRelPower 63.3839
tremorGyroAmpMean 0.0794253
tremorGyroAmpSlope -0.00799835
tremorGyroAmpCoV 0.358949
tremorCoordAmpMean 0.161231
tremorCoordAmpSlope -0.00377113
tremorCoordAmpCoV 0.257694
tremorAccAmpMean 0.149281
tremorAccAmpSlope -0.00430568
tremorAccAmpCoV 0.308856
tremorPcRelVar 0.755444
tremorPcX -0.665287
tremorPcY 0.746588

ZigZag Segment 1

Duration 19.4 s, Accuracy Estimate 2.512 (lower is better)

ZigZag Segment 2

Duration 17.12 s, Accuracy Estimate 2.145 (lower is better)

ZigZag Segment 3

Duration 17.48 s, Accuracy Estimate 2.478 (lower is better)

ZigZag Segment 4

Duration 17.44 s, Accuracy Estimate 2.358 (lower is better)

ZigZag Segment 5

Duration 17.64 s, Accuracy Estimate 2.324 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 12.152
timePerZigzagCoV 0.102264
timePerZigzagSlope 0.0325872
zigzagHeightMean 79.6725
zigzagHeightCoV 0.0285847
zigzagHeightSlope -0.00846386
meanError 0.0510092
tremorFreq 6.15234
tremorRelPower 60.4339
tremorGyroAmpMean 0.09532
tremorGyroAmpSlope -0.00622264
tremorGyroAmpCoV 0.190905
tremorCoordAmpMean 0.235591
tremorCoordAmpSlope 0.00223317
tremorCoordAmpCoV 0.193568
tremorAccAmpMean 0.226618
tremorAccAmpSlope 0.000890649
tremorAccAmpCoV 0.171721
tremorPcRelVar 0.752315
tremorPcX -0.5715
tremorPcY 0.820602

ZigZag Offset Segment 1

Duration 10.08 s, Accuracy Estimate 0.1 (lower is better)

ZigZag Offset Segment 2

Duration 12.84 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 3

Duration 12.8 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 4

Duration 13.12 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 5

Duration 11.92 s, Accuracy Estimate 0.047 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.7}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.5071468678318789}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9291957502043613}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}